کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2829927 | 1163327 | 2010 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A decade of epigenetic research in Toxoplasma gondii A decade of epigenetic research in Toxoplasma gondii](/preview/png/2829927.png)
In the past 10 years, the field of parasitology has witnessed an explosion of studies investigating gene regulation. In this review, we will describe recent advances largely stemming from the study of Toxoplasma gondii, a significant opportunistic pathogen and useful model for other apicomplexan protozoa. Surprising findings have emerged, including the discovery of a wealth of epigenetic machinery in these primitive eukaryotes, unusual histone variants, and a battery of plant-like transcription factors. We will elaborate on how these unusual features impact parasite physiology and potential therapeutics as we summarize some of the key discoveries from the last decade. We will close by proposing a few questions to address in the next 10 years.
Our review describes advances in Toxoplasma epigenetic research during the last 10 years.Figure optionsDownload high-quality image (198 K)Download as PowerPoint slide
Journal: Molecular and Biochemical Parasitology - Volume 173, Issue 1, September 2010, Pages 1–9