کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2830700 1163750 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between the complement system, risk factors and prediction models in age-related macular degeneration
ترجمه فارسی عنوان
رابطه بین سیستم مکمل، عوامل خطر و مدل های پیش بینی در دژنراسیون ماکولا مرتبط با سن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
چکیده انگلیسی


• Association of complement system with AMD risk factors and AMD prediction models.
• This information would improve our understanding of AMD pathology.
• Could lead to better clinical management of AMD patients.
• Targeting complement system is potentially beneficial for the treatment of AMD.

Studies performed over the past decade in humans and experimental animals have been a major source of information and improved our understanding of how dysregulation of the complement system contributes to age-related macular degeneration (AMD) pathology. Drusen, the hall-mark of dry-type AMD are reported to be the by-product of complement mediated inflammatory processes. In wet AMD, unregulated complement activation results in increased production of angiogenic growth factors leading to choroidal neovascularization both in humans and in animal models. In this review article we have linked the complement system with modifiable and non-modifiable AMD risk factors as well as with prediction models of AMD. Understanding the association between the complement system, risk factors and prediction models will help improve our understanding of AMD pathology and management of this disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 63, Issue 2, February 2015, Pages 176–183
نویسندگان
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