کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2832027 | 1570739 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
All oligosaccharide moieties of the μ chains in the pre-BCR are of the high-mannose type
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کلمات کلیدی
BCRμMμsendoglycosidase Fendo F - اندو FEndo H - اندو هendoglycosidase H - اندوگلیکوزیداز HB cell differentiation - تمایز سلول BH chain - زنجیره HL chain - زنجیره Llight chain - زنجیره سبکsurrogate light chain - زنجیره سبک جایگزینheavy chain - زنجیره سنگینGlycosylation - گلیکوزیله شدنB cell receptor - گیرنده سلول Bpre-B cell receptor - گیرنده سلول پیش از ب
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Although it is well established that pre-BCR signaling governs proliferation and differentiation during B cell development, the components of the pre-BCR that are important for signaling are a matter of controversy. It has been suggested that signaling by the μ heavy chains of the pre-BCR induces survival and differentiation of pre-B cells, while the λ5 part of the pre-BCR is essential for proliferation and clonal expansion. However, the mechanism by which pre-BCR μ chains initiate differentiation signals is not clear. Using two variants of a murine B-lymphocyte cell line that differ only in surface expression of either BCR or pre-BCR, we demonstrated that surface μ chains in the pre-BCR are of the high-mannose type only, while those in the BCR are of the complex type. It is hypothesized that mannose-specific lectin-like molecules on accessory cells or in solution may function as the non-antigen ligand that triggers the pre-BCR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 48, Issues 1â3, NovemberâDecember 2010, Pages 351-355
Journal: Molecular Immunology - Volume 48, Issues 1â3, NovemberâDecember 2010, Pages 351-355
نویسندگان
Joseph Haimovich, Natalie Ben Moshe, Yasmin Raviv, Nurit Hollander,