Keywords: زنجیره سبک; Amyloidosis; AL amyloidosis; light chain; lambda; collapsing glomerulopathy; amyloid nephropathy; paraprotein; deposition; acute kidney injury (AKI); nephrotic syndrome; immunoglobulin; renal biopsy; case report;
مقالات ISI زنجیره سبک (ترجمه نشده)
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Keywords: زنجیره سبک; Botulinum neurotoxin; 3,4-Diaminopyridine; Isometric muscle contractions; Endplate recordings; Neurotransmission; Release probability; BoNT; botulinum neurotoxin; DAP; 3,4-diaminopyridine; HC; heavy chain; LC; light chain; NMJ; neuromuscular junction; EPP
Keywords: زنجیره سبک; CA; caprylic acid; mAb; monoclonal antibody; Ig; immunoglobulin; HCP; host cell protein; CHO; Chinese hamster ovary; LC; light chain; HC; heavy chain; MCBS; multi-component buffer system; TCID50; 50% tissue culture infectious dose; MuLV; murine leukemia v
Oxidative post-translational modifications of an amyloidogenic immunoglobulin light chain protein
Keywords: زنجیره سبک; Ig; Immunoglobulin; AL; immunoglobulin light chain amyloidosis; LC; light chain; FLC; free light chain; ROS; reactive oxygen species; MPO; myeloperoxidase; LDL; low-density lipoprotein; DTT; dithiothreitol; IAA; 2-iodoacetamide; (DNPH); 2,4-dinitrophenylh
Comparability study of Rituximab originator and follow-on biopharmaceutical
Keywords: زنجیره سبک; AA; amino acid; ABC; ammonium bicarbonate; ACN; acetonitrile; ADCC; antibody-dependent cellular cytotoxicity; CD; circular dichroism; CDC; complement-dependent cytotoxicity; CDRs; complementarity determining regions; CH; constant region of heavy chain; CH
Identification and characterization of monoclonal antibody fragments cleaved at the complementarity determining region using orthogonal analytical methods
Keywords: زنجیره سبک; CE-SDS; sodium dodecyl sulfate capillary electrophoresis; mAb; monoclonal antibody; RP-LC-MS; reversed phase liquid chromatography mass spectrometry; CDR; complementarity determining region; SEC-HPLC; size exclusion liquid chromatography; dSEC-HPLC; d
Keywords: زنجیره سبک; cTnT; Cardiac troponin T; CPHPC; R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid; EGCG; epigallocethechin-3-gallate; FLC-diff; difference between involved and uninvolved serum free light chain; FDA; Food and Drug Administ
Keywords: زنجیره سبک; bortezomib; congestive heart failure; cyclophosphamide; infiltrative cardiomyopathy; light chain; melphalan; AL; immunoglobulin light chain; BDex+AA; bortezomib, dexamethasone, and alkylating agent; CI; confidence interval; dFLC; free light-chain differen
Keywords: زنجیره سبک; Disulfide linkage; Disulfide scrambling; Therapeutic mAbs; Peptide mapping; Nonreducing; LC-MS; mAb; monoclonal antibody; IgG; immunoglobulin G; HC; heavy chain; LC; light chain; VL; variable domain of light chain; CL; constant domain of light chain; VH
Keywords: زنجیره سبک; Ag; antigen; bnAb; broadly neutralizing anti-HIV Ig; CLL; chronic lymphocytic leukemia; EBV; Epstein Barr virus; GBM; glomerular basement membrane; GN; glomerulonephritis; GP; Goodpasture; GPS; GP syndrome; HC; heavy chain; HCDR3; heavy chain complementar
Keywords: زنجیره سبک; IgG; immunoglobulin G; mAb; monoclonal antibody; CHO; Chinese hamster ovary; HCP; host cell proteins; nh-HCP; non-histone host cell proteins; HC; heavy chain; LC; light chain; CCS; cell culture supernatant; c-d CCS; chromatin-directed clarified CCS; CV; c
Keywords: زنجیره سبک; Biological toxins; Ricin; Botulinum neurotoxin; Staphylococcal enterotoxin; Saxitoxin; Standardization; Proficiency testing; AOAC; AOAC International; BoNT; Botulinum neurotoxin; CRM; Certified reference material; CWC; Chemical Weapons Convention; EFSA; E
Keywords: زنجیره سبک; 2D-LC; two-dimensional liquid chromatography; AA; amino acid; AC; affinity chromatography; ADC; antibody-drug conjugates; ADCC; antibody-dependent cellular cytotoxicity; AF4; asymmetric flow field fractionation; APTS; 1-aminopyrene-3,6,8-trisulfonate; Asn
Keywords: زنجیره سبک; Botulinum neurotoxin; Botulism; Synaptotagmin; Synaptic vesicle glycoprotein 2; Protein complex; Host-pathogen recognition; botulinum neurotoxin; BoNT; light chain; LC; heavy chain; HC; N-terminal domain of HC; HN; C-terminal domain of HC; HC; N-terminal
Keywords: زنجیره سبک; Polysialic acid; Tegaserod; Mimetic; Peripheral nerve; Regeneration; Glycan; Drug repurposing; CDR; complementary determining region; cGN; cerebellar granule neuron; DRG; dorsal root ganglion; ELISA; enzyme-linked immunosorbent assay; FBA; foot base angle
Keywords: زنجیره سبک; Bacillus anthracis; Anthrax; Lethal factor; Botulinum neurotoxin A; Light chain; Zinc metalloprotease; Matrix metalloprotease; Quinoline; Hybrid compound; Desymmetrized;
Keywords: زنجیره سبک; Protein translocase; Biological weapons; Botulism; Antibotulinal agents; Modular nanomachine; βME; beta-mercaptoethanol; ÎpH; pH gradient across the cis and trans compartments; γ; single channel conductance; BoNT; botulinum neurotoxin; BTD; beltless tr
Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls
Keywords: زنجیره سبک; Fab; monovalent Fragment-antigen binding; F(ab')2; bivalent Fab; Fc/2; constant fragment of IgG heavy chain; Fd; variable fragment of IgG heavy chain; LC; light chain; IdeS; cysteine protease from Streptococcus pyogenes; IgdE; cysteine protease from Str
Prognostic and Added Value of Two-Dimensional Global Longitudinal Strain for Prediction of Survival in Patients with Light Chain Amyloidosis Undergoing Autologous Hematopoietic Cell Transplantation
Keywords: زنجیره سبک; AL amyloidosis; Autologous hematopoietic cell transplantation; Global longitudinal strain; Serum cardiac biomarkers; Survival; 2D; Two-dimensional; AL; Light chain; BNP; Brain natriuretic peptide; CR; Complete hematologic remission; GLS; Global longitudin
Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy
Keywords: زنجیره سبک; bsAb; bispecific antibody; CHO; chinese hamster ovary; ER; endoplasmic reticulum; IgG; Immunoglobulin G; DTE; difficult-to-express; DHFR; dihydrofolate reductase; MTX; Methotrexate; VCD; viable cell density; qRT-PCR; quantitative real-time polymerase chai
In vitro potency determination of botulinum neurotoxin serotype A based on its receptor-binding and proteolytic characteristics
Keywords: زنجیره سبک; Botulinum neurotoxin serotype A (BoNT/A); In vitro assay; Binding and cleavage assay (BINACLE assay); Activity determination; BINACLE; Binding and cleavage assay; BoNT; Botulinum neurotoxin; BSA; Bovine serum albumin; GT1b; Trisialoganglioside GT1b; H-cha
Rational design of botulinum neurotoxin A1 mutants with improved oxidative stability
Keywords: زنجیره سبک; Light chain; BoNT/A; Toxin; Oxidative stability; Protein stability; Protein design;
Rationale and design of DUAL study: Doxycycline to Upgrade response in light chain (AL) amyloidosis (DUAL): A phase 2 pilot study of a two-pronged approach of prolonged doxycycline with plasma cell-directed therapy in the treatment of AL amyloidosis
Keywords: زنجیره سبک; Phase 2 clinical trial; Doxycycline; Amyloidosis; Light chain; Chemotherapy;
Comparison of SEC and CE-SDS methods for monitoring hinge fragmentation in IgG1 monoclonal antibodies
Keywords: زنجیره سبک; CE-SDS; SEC; Fragmentation; Antibody; Electrophoresis; IgG; immunoglobulin; HC; heavy chain; LC; light Chain; HL; heavy-light; HH; heavy-heavy; HHL; heavy-heavy-light; NGH; non-glycosylated heavy chain; LMW; low molecular weight; mAb; monoclonal antibody;
Influences of HLA DRB1, DQA1 and DQB1 on T-cell recognition of epitopes and of larger regions of the botulinum neurotoxin molecule
Keywords: زنجیره سبک; BoNT/A; Clostridium botulinum neurotoxin type A; LC; light chain; HC; carboxyl terminal domain of the heavy chain; HN; amino terminal domain of the heavy chain; HLA; Human leukocyte antigen; DR; HLA DR-region (class II MHC) isoform composed of αβx; DRB1
Design of modified botulinum neurotoxin A1 variants with a shorter persistence of paralysis and duration of action
Keywords: زنجیره سبک; Duration of actions; C-terminus; Light chain; BoNT/A; Faster onset of effect; Toxin;
A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A
Keywords: زنجیره سبک; BoNTs; botulinum neurotoxins; BoNT/A; botulinum neurotoxin serotype A; HC; heavy chain; LC; light chain; SNARE; soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SNAP-25; 25Â kDa synaptosomal-associated protein; BIG-IV; Botulism Immun
Immuno-detection of cleaved SNAP-25 from differentiated mouse embryonic stem cells provides a sensitive assay for determination of botulinum A toxin and antitoxin potency
Keywords: زنجیره سبک; BoNT/A; botulinum neurotoxin A; SNAP-25; synaptosomal protein of molecular mass 25Â kDa; EB; embryoid bodies; ESDN; embryonic stem cell-derived neurons; mESC; mouse embryonic stem cells; HC; heavy chain; LC; light chain; LHn/A; recombinant endopeptidase f
Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis
Keywords: زنجیره سبک; Ab; Antibodies; ADCC; Antibody-dependent cellular cytotoxicity; Ag; Antigen; BLAST; Basic local alignment search tool; BSA; Bovine serum albumin; CDC; Complement-dependent cytotoxicity; CDRs; Complementarity determining regions; CHO; Chinese hamster ovary
Sequential screening by ClonePix FL and intracellular staining facilitate isolation of high producer cell lines for monoclonal antibody manufacturing
Keywords: زنجیره سبک; ClonePix FL; NS0; Chinese hamster ovary cells; Intracellular staining; Flow cytometry high throughput screening; IgG expression; Heavy chain; Light chain; Probability of monoclonality; Semi-solid media;
A new anti-human Fc method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in serum from pre-clinical species
Keywords: زنجیره سبک; ADC; antibody drug conjugates; DAR; drug to antibody ratio; Fc; fragment crystallizable HC heavy chain; IgG; immunoglobulin G; LC; light chain; LC-MS; liquid chromatography-mass spectrometry; mAb; monoclonal antibody; RT; room temperature; ELISA; enzy
In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics
Keywords: زنجیره سبک; BINACLE; binding and cleavage assay; BoNT; botulinum neurotoxin; BSA; bovine serum albumin; GT1b; ganglioside GT1b; H-chain; heavy chain; HCc; C-terminal region of the H-chain; L-chain; light chain; LD50; lethal dose for 50% of test animals; NAP; neurotox
BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo
Keywords: زنجیره سبک; AL; light chain; ANF; atrial natriuretic factor; ÃMHC; beta myosin heavy chain; BNP; brain natriuretic peptide; BRM; Brahma (aka SMARCA2); BRG1; Brahma-related gene 1 (aka SMARCA4); CHOP; CCAAT/-enhancer-binding protein homologous protein; ER; endoplasmi
The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains
Keywords: زنجیره سبک; AUC; analytical ultracentrifugation; C-domain; constant domain; Ig; immunoglobulin; LC; light chain; MS; mass spectrometry; PBS; phosphate-buffered saline; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; SEC; size-exclusion chromatogr
Expression and biochemical characterization of light chains of Botulinum neurotoxin subtypes F5 and F7
Keywords: زنجیره سبک; Botulinum neurotoxin serotype F; Light chain; Expression; Biochemical characterization; F5; F7;
ReviewBotulinum neurotoxin type A: Actions beyond SNAP-25?
Keywords: زنجیره سبک; BoNT/A; botulinum neurotoxin type A; HC; heavy chain; LC; light chain; SNAP-25; synaptosomal-associated protein of 25Â kDa; SV2; synaptic vesicle protein 2; SNARE; soluble N-ethylmaleimide-sensitive factor attachment protein receptor; VAMP; vesicle-associ
Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding
Keywords: زنجیره سبک; LC; light chain; VL; variable Light chain domain; CL; constant domain; FL; full length light chain; BJP; Bence-Jones proteins; ThT; Thioflavin T; T*; temperature reference independent of the applied scan rate, âHâ¡, enthalpy reference independent of th
Genomics of Clostridium botulinum group III strains
Keywords: زنجیره سبک; Clostridium botulinum group III; Neurotoxin; Progenitor toxin; C2 toxin; C3 exoenzyme; Phage conversion; NTX; neurotoxin; L; light chain; Hn; N-terminal region of heavy chain; Hc; C-terminal region of heavy chain; PTX; progenitor toxin; HA; hemagglutinin;
Interactions of a potent cyclic peptide inhibitor with the light chain of botulinum neurotoxin A: Insights from X-ray crystallography
Keywords: زنجیره سبک; BoNT; botulinum neurotoxin; Balc; botulinum neurotoxin A light chain; Balc424; Balc truncated at residue 424; Balc448; full-length Balc; CPI-1; cyclic peptide inhibitor-1; CPI-2; cyclic peptide inhibitor-2; DAB; 2,4-diaminobutanoic acid; FRET; Förster re
Characterization of cysteine related variants in an IgG2 antibody by LC-MS with an automated data analysis approach
Keywords: زنجیره سبک; IgG2; Monoclonal antibody; Disulfide; Free sulfhydryls and cysteine; LC-MS; nrRP-HPLC; Pinpoint software; ACN; acetonitrile; AEX; anion-exchange chromatography; CEX; cation-exchange chromatography; CHO; Chinese hamster ovary; ESI; electrospray ionizatio
Transcriptome analysis of a CHO cell line expressing a recombinant therapeutic protein treated with inducers of protein expression
Keywords: زنجیره سبک; CHO; Chinese hamster ovary; DHFR; dihydrofolate reductase; GO; gene ontology; GS; glutamine synthetase; GSEA; gene set enrichment analysis; HC; heavy chain; HMBA; hexamethylene bisacetamide; IgG1; human immunoglobulin G1; IRES; internal ribosome entry sit
The N-terminal strand modulates immunoglobulin light chain fibrillogenesis
Keywords: زنجیره سبک; Light chain; Amyloid; Misfolding; Aggregation; Folding thermodynamics;
Assessment of naturally occurring covalent and total dimer levels in human IgG1 and IgG2
Keywords: زنجیره سبک; DTT; dithiothreitol; EDTA; ethylene diamine tetraacetic acid; GFB; glufibrinopeptide B; HC; heavy chain; HL; half molecule; LC; light chain; LC/MS; liquid chromatography/mass spectrometry; NEM; N-ethylmaleimide; SDS-PAGE; sodium dodecyl sulfate-polyacryla
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain
Keywords: زنجیره سبک; BafA1; bafilomycin A1; BoNT/X; botulinum neurotoxin/serotype X; CGNs; cerebellar granule neurons; FBS; foetal bovine serum; HC; heavy chain; HC; C-terminal half of HC; HCC; C-terminal domain of the HC-fragment; HCN; N-terminal domain of the HC-fragment; H
Easy expression of the C-terminal heavy chain domain of botulinum neurotoxin serotype A as a vaccine candidate using a bi-cistronic baculovirus system
Keywords: زنجیره سبک; ACh; acetylcholine; AcMNPV; Autographa californica multiple polyhedrosis virus; BEVS; baculovirus expression vector system; BoNT/A; botulinum toxin A; EGFP; enhanced green fluorescent protein; ELISA; enzyme-linked immunosorbent assay; HC; heavy chain; IMA
Engineering Clostridia Neurotoxins with elevated catalytic activity
Keywords: زنجیره سبک; Botulinum Neurotoxin B; TeNT; Light chain; VAMP2; Engineering; Elevated activity; CNTs; Clostridia Neurotoxins; BoNT/B; Botulinum Neurotoxin; TeNT; Tetanus Neurotoxin; LC; light chain; VAMP2; vesicle associated membrane protein-2; SNARE; soluble NSF attac
Therapeutic effectiveness of botulinum neurotoxin A: Potent blockade of autonomic transmission by targeted cleavage of only the pertinent SNAP-25
Keywords: زنجیره سبک; SNAREs; Autonomic neurons; Acetylcholine; Neurotherapeutics; ACSF; artificial cerebrospinal fluid; BoNT; botulinum neurotoxin; BoNT/A - G; BoNT type A - G; DAPI; 4â²,6-diamidino-2-phenylindole; HC and HN; C- and N-terminal halves of the toxins' heavy
Effects of enzymatically inactive recombinant botulinum neurotoxin type A at the mouse neuromuscular junctions
Keywords: زنجیره سبک; Non-toxic botulinum neurotoxin A; Neuromuscular junction; Acetylcholine release; Nerve muscle preparation; Deactivated; Recombinant botulinum neurotoxin A; BoNT/A; Botulinum neurotoxin A; DrBoNT/A; deactivated recombinant BoNT/A; ACh; acetylcholine; NMPs;
B-cell biology and development
Keywords: زنجیره سبک; B cell; B lymphocyte; immunodeficiency; development; humoral immunity; autoimmunity; tolerance; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B-cell activator of the TNF-α family (aka BLYS); BAFF-R; BAFF recept
Judging disease activity in rheumatoid arthritis by serum free kappa and lambda light chain levels
Keywords: زنجیره سبک; Disease activity; Disease activity score; Light chain; Rheumatoid arthritis