کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2832805 1163848 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions
چکیده انگلیسی

Progressive interaction with other cells is critical to all aspects of T-cell biology – from migration through tissues, to recognition of antigen-presenting cells. We demonstrate a novel mechanism for regulating T lymphocyte adhesion and thus cell–cell interactions, showing that T-cell-expressed EphA and ephrin-A proteins not only regulate adhesive properties, but do so in a diametrically opposing fashion. Integrin-mediated adhesion is stimulated by ephrin-A activation, while EphA signalling is inhibitory. Increasing ephrin-A expression enhances T-cell interactions not only with purified integrin ligands but also endothelial cells, while EphA activation down-regulates these interactions. In accordance with an in vivo role for these proteins in regulating cell–cell interactions, activation of ephrin-A signalling was found to alter the trafficking of injected T lymphocytes to peripheral lymph nodes in vivo. Given the ubiquitous nature of EphA/ephrin-A expression in tissues, these proteins likely play a significant role in regulating T-cell interactions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 45, Issue 5, March 2008, Pages 1208–1220
نویسندگان
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