La LDL agregada induce la expresión y la activación de factor tisular en células vasculares mediante un mecanismo inhibible por pravastatina

AgLDL internalization increases TF expression and activation through Rho A activation while pravastatin prevents this effect by impairing Rho A traslocation. Our results help to explain the major role of Rho A activation in the pathogenesis of atherothrombosis and the potential of statins in atherothrombosis prevention.