کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2842386 | 1571039 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Orchestration of gene expression and physiology by the circadian clock
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Orchestration of gene expression and physiology by the circadian clock Orchestration of gene expression and physiology by the circadian clock](/preview/png/2842386.png)
چکیده انگلیسی
In mammals, the master circadian clock that drives many biochemical, physiological and behavioral rhythms is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. Generation and maintenance of circadian rhythms rely on complex interlaced feedback loops based on transcriptional and posttranscriptional events involving clock genes and kinases. This clock serves the purpose to organize an organism's biochemistry on a 24Â h time scale thereby avoiding interference between biochemical pathways and optimizing performance. Synchronization to environmental 24Â h oscillations tunes physiological processes optimally with nature. In this review, I briefly describe the principle of the clock mechanism, its synchronization to the environment and consequences on health when the circadian clock is disrupted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Physiology-Paris - Volume 100, Issues 5â6, NovemberâDecember 2006, Pages 243-251
Journal: Journal of Physiology-Paris - Volume 100, Issues 5â6, NovemberâDecember 2006, Pages 243-251
نویسندگان
Urs Albrecht,