کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2843782 | 1571108 | 2006 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cyclooxygenase: Past, present and future. A tribute to John R. Vane (1927–2004) Cyclooxygenase: Past, present and future. A tribute to John R. Vane (1927–2004)](/preview/png/2843782.png)
Study of the prostaglandins led directly to the elucidation of the mode of action of aspirin which inhibits their synthesis. John Vane elegantly demonstrated in 1971 that non-steroid anti-inflammatory drugs (NSAIDs) blocked cyclooxygenase (COX), the enzyme which makes prostaglandins. In 1991, Daniel Simmons described the gene which expresses a second cyclooxygenase, COX-2. This discovery explained the anti-inflammatory actions of NSAIDs, inhibition of COX-2, and their side actions, inhibition of COX-1. Within 8 years selective COX-2 inhibitors became available for the treatment of inflammation without the disadvantage of gastric toxicity. Recently, a COX-1 variant protein, named COX-3, sensitive to inhibition with acetaminophen, was characterised, cloned and expressed.
Journal: Journal of Thermal Biology - Volume 31, Issues 1–2, January 2006, Pages 208–219