کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848505 1167426 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of humidity on lung surfactant films subjected to dynamic compression/expansion cycles
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Effect of humidity on lung surfactant films subjected to dynamic compression/expansion cycles
چکیده انگلیسی

The surface activity of bovine lipid extracted surfactant (BLES) preparations used in surfactant replacement therapy is studied in dynamic film compression/expansion cycles as a function of relative humidity, surfactant concentration, compression rate, and compression periodicity. BLES droplets were formed in a constrained sessile droplet configuration (CSD). Images obtained during cycling were analyzed using axisymmetric drop shape analysis (ADSA) to yield surface tension, surface area, and drop volume data. The experiments were conducted in a chamber that allowed both humid (100% RH), and “dry” air (i.e. less than 20% RH) environments. It was observed that in humid environments BLES films are not stable and tend to have poor surface activity compared to BLES films exposed to dry air. Further analysis of the data reveal that if BLES films are compressed fast enough (i.e. at physiological conditions) to avoid film hydration, lower minimum surface tensions are achieved. A film hydration–relaxation mechanism is proposed to explain these observations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 155, Issue 3, 15 March 2007, Pages 255–267
نویسندگان
, , , , , , ,