Effect of Losartan Versus Candesartan on Uric Acid, Renal Function, and Fibrinogen in Patients With Hypertension and Hyperuricemia Associated With Diuretics

Candesartan and losartan lowered BP, but only losartan reduced uric acid. The lowering of fibrinogen in both groups may explain the reduction in stroke with angiotensin receptor blockers. The effect of persistent hyperuricemia on renal function requires further study.