Management of Hyperkalemia in Hospitalized Patients

PurposeThe aim of this study was to determine the incidence of treatment of hyperkalemia in hospitalized patients.MethodsThis is a prospective chart review of adults in a tertiary care hospital with hyperkalemia (serum potassium [K+] ≥ 5.1 mEq/L) over a 6-month period. The treatments and their effectiveness, causative factors and associated electrocardiographic (ECG) changes were examined.ResultsThere were 154 hyperkalemic episodes, 32 with K+ ≥ 6.5 mEq/L and 122 with K+< 6.5 mEq/L. Overall, 97% received treatment for an average K+ of 5.9 mEq/L. Sodium polystyrene sulfonate (SPS) was included in 95% of the regimens. incremental doses of sPs monotherapy yielded potassium reductions between 0.7 and 1.1 mEq/L, and inadequate responses (K+ < 0.5 mEq/L) were less frequent with higher doses. There were no differences in the effectiveness of SPS among dialysis-dependent, chronic kidney disease, or nonchronic kidney disease patients. Greater reductions in potassium were observed using a combination of treatments. ECGs were performed in 44% of patients, and 50% showed no ECG changes despite K+ being ≥ 6.5 mEq/L. The most common abnormality, peaked T waves, was associated with a higher frequency of calcium administration but not with the number of K+-lowering therapies.ConclusionsAlmost all the patients were treated for hyperkalemia. Oral SPS monotherapy was the predominant treatment with the best response at the highest dose. Some combination therapies had greater K+ reductions but were used infrequently. An ECG was obtained in about 50% of the cases, but two thirds showed no K+-related changes. Reduced kidney function was associated with 70% of hyperkalemic episodes. Angiotensin-converting enzyme inhibitors and trimethoprim were the most commonly implicated medications.