Chronic Direct Renin Inhibition With Aliskiren Prevents the Development of Hypertension in Cyp1a1-Ren2 Transgenic Rats With Inducible ANG II-Dependent Hypertension

The present findings demonstrate that chronic direct renin inhibition with aliskiren prevents the development of ANG II-dependent hypertension and the associated derangements in renal hemodynamics and excretory function in Cyplal-Ren2 transgenic rats.