کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2865300 1573205 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A B-Cell Lymphoma Diagnosed in “Floater” Tissue: Implications of the Diagnosis and Resolution of a Laboratory Error
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
A B-Cell Lymphoma Diagnosed in “Floater” Tissue: Implications of the Diagnosis and Resolution of a Laboratory Error
چکیده انگلیسی
Contamination of a paraffin-embedded tissue block with another patient's tissue can lead to an incorrect diagnosis. We report the use of short tandem repeats for the analysis of DNA extracted from microdissected tissue from unstained slides prepared from a decalcified block from a 33-year-old woman who was previously diagnosed with a low-grade B-cell lymphoma. This diagnosis was based on a single fragment of tissue found among bone fragments taken during orthopedic surgery at a referring hospital. Our results confirm that the B-cell lymphoma tissue was not derived from our patient. Furthermore, we suggest that in cases for which the definitive identification of a tissue contaminant can resolve clinically, therapeutically, and prognostically significant questions, short tandem repeat analysis of DNA derived from microdissected surgical pathology samples should be considered to minimize errors and enhance the quality of care.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of the Medical Sciences - Volume 338, Issue 3, September 2009, Pages 248-251
نویسندگان
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