Modified In Vivo Lung Perfusion for Local Chemotherapy: A Preclinical Study With Doxorubicin

IVLP for 4 hours with Dox 75 mg/m2 alone or combined with Ifos was well tolerated, without measurable ALI. High drug levels in perfusate and lung tissue were found without systemic leakage. A dose-related toxicity was observed with increases in Dox doses.