کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2893022 1172403 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke
چکیده انگلیسی

No study has yet evaluated the relationship between arterial stiffness indexes and immuno-inflammatory pathway in patients with an acute cardiovascular or cerebrovascular event. The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immune-inflammatory markers and arterial stiffness indexes.Methods107 subjects with acute ischemic stroke and 107 controls without stroke. We evaluated plasma levels of C-reactive protein (CRP), interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10), E-selectin, P-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), von Willebrand Factor (vWF), tissue plasminogen activator (TPA), plasminogen activator inhibitor-1 (PAI-1). Carotid-femoral pulse wave velocity (PWV) and augmentation index (Aix) were evaluated.ResultsThere was a significant positive relationship, corrected for age, and gender, between PWV and CRP, TNF-α, IL1β, VWF and IL-6. Aix was significantly related to VWF, IL-6 and TNF-α levels. Among Lacunar subtype PWV was significantly related to CRP, IL-1β, IL-6, TNF-α and vWF. In LAAS subjects PWV was significantly related to CRP, IL-1β, IL-6, TNF-α but not with vWF. Among CEI subtype, PWV was significantly and positively related to CRP, IL-1β, TNF-α and vWF.DiscussionOur findings show that both aortic stiffness and wave reflection are related to the degree of systemic inflammation in stroke subjects, suggesting that circulating inflammation mediators can influence the stiffness of vessels distant to those involved in the disease process itself.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 213, Issue 1, November 2010, Pages 311–318
نویسندگان
, , , , , , ,