کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2893111 1172404 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of Lp-PLA2 activity with allele-specific Lp(a) levels in a bi-ethnic population
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Association of Lp-PLA2 activity with allele-specific Lp(a) levels in a bi-ethnic population
چکیده انگلیسی

ObjectivesLipoprotein-associated phospholipase A2 (Lp-PLA2) and lipoprotein(a) [Lp(a)] have been implicated as cardiovascular disease risk factors, and are differentially regulated across ethnicity. We investigated the association between Lp-PLA2 activity and allele-specific apolipoprotein(a) [apo(a)] levels in a bi-ethnic population.MethodsLp-PLA2 activity, Lp(a) and allele-specific apo(a) levels were determined in 224 African Americans and 336 Caucasians.ResultsLp-PLA2 activity level was higher among Caucasians compared to African Americans (173 ± 41 nmol/min/ml vs. 141 ± 39 nmol/min/ml, P < 0.001), and positively associated with Lp(a), total and LDL cholesterol, triglyceride, apolipoprotein B-100, and negatively with HDL cholesterol levels in both ethnic groups. The association between Lp-PLA2 activity and Lp(a) was stronger among African Americans compared to Caucasians (R = 0.238, β1 = 3.48, vs. R = 0.111, β1 = 1.93, respectively). The Lp-PLA2 activity level was significantly associated with allele-specific apo(a) levels for smaller (<26 K4 repeats) apo(a) sizes in both ethnic groups (P = 0.015 for African Americans, P = 0.038 for Caucasians). In contrast, for larger (>26 K4 repeats) apo(a) sizes, high Lp-PLA2 activity levels were associated with higher allele-specific apo(a) levels in African Americans (P = 0.009), but not in Caucasians.ConclusionThe association between Lp-PLA2 activity and allele-specific apo(a) levels differs across African American-Caucasian ethnicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 211, Issue 2, August 2010, Pages 526–530
نویسندگان
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