کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2894199 | 1172429 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hepatitis B virus seropositivity is not associated with increased risk of carotid atherosclerosis in Taiwanese Hepatitis B virus seropositivity is not associated with increased risk of carotid atherosclerosis in Taiwanese](/preview/png/2894199.png)
BackgroundChronic infection has been proposed to increase the risk of atherosclerosis in several experimental and epidemiological studies. However, the relationship of chronic hepatitis B virus (HBV) infection and atherosclerosis remains controversial. We conducted this cross-sectional study to evaluate the association of carotid atherosclerosis with hepatitis B seropositivity.Methods and resultsIn this cross-sectional study, we collected data from subjects undergoing health examination, including B-mode carotid ultrasonography, hepatitis B surface antigen (HBsAg) status and assessment of traditional cardiovascular risk factors, at our institutes in Taiwan between 2002 and 2003. Cases with chronic hepatitis C had been excluded. Of the 508 eligible subjects, 87 (17.1%) were positive for HBsAg and only six of them were positive for HBeAg. Compared with HBsAg negative subjects, the ORs (and 95% CIs) for the subjects with chronic hepatitis B to have carotid atherosclerosis were 1.24 (0.73–2.10) indexed by the presence of carotid atherosclerotic plaque (Intima-media thickness, IMT ≥ 1.3 mm), 0.74 (0.38–1.42) by maximal common carotid artery IMT ≥ 75th percentile, and 1.09 (0.62–1.90) by extracranial carotid artery atherosclerotic score ≥ 2, with the use of multivariate logistic regression analyses.ConclusionHepatitis B virus seropositivity was not associated with an increased severity of carotid atherosclerosis in Taiwanese.
Journal: Atherosclerosis - Volume 195, Issue 2, December 2007, Pages 392–397