کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2894217 | 1172429 | 2007 | 7 صفحه PDF | دانلود رایگان |
ObjectivesAn optimized, longitudinal in vivo magnetic resonance vessel wall-imaging protocol was evaluated regarding its capability of detecting differences in the time-dependent atherosclerotic lesion progression in the aortic arch between ApoE−/− and double-deficient ApoE−/−/TNF−/− mice at comparatively early plaque development stages.Materials and methodsSeven ApoE−/− and seven ApoE−/−/TNF−/− female mice underwent MRI at 11.75 teslas at four stages up to 26 weeks of age. A double-gated spin-echo MRI sequence was used with careful perpendicular slice positioning to visualize the vessel wall of the ascending aortic arch.ResultsWall-thickness progression measured with MRI was significant at 11 weeks of age in ApoE−/− mice, but only at 26 weeks in ApoE−/−/TNF−/− mice. A significant correlation was found between MRI wall-thickness and lesion area determined on histology.ConclusionMRI was shown to be sensitive enough to reveal subtle genetically-induced differences in lesion progression at ages earlier than 25 weeks.
Journal: Atherosclerosis - Volume 195, Issue 2, December 2007, Pages e93–e99