کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2894243 1172430 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Statin-associated adverse effects beyond muscle and liver toxicity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Statin-associated adverse effects beyond muscle and liver toxicity
چکیده انگلیسی

Randomized controlled trials with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have consistently demonstrated significant reductions in cardiovascular morbidity and mortality. Statins are currently the most widely used drugs in many countries. The most important adverse effects are associated with muscle and liver toxicity. However, with increased use and dose of statins and their over-the-counter availability in some countries more cases of other rare side effects may be seen in clinical practice. In the present article we review the literature concerning the statin-related adverse effects other than muscle and liver injury and we provide insight into their clinical revelance and possible underlying mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 195, Issue 1, November 2007, Pages 7–16
نویسندگان
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