کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2894292 | 1172430 | 2007 | 9 صفحه PDF | دانلود رایگان |
The ATP-binding cassette transporter A-1 (ABCA1) regulates cholesterol efflux from cells and is involved in high-density lipoprotein (HDL) metabolism and atherogenesis. We investigated whether common ABCA1 variants, previously reported to have phenotypic effects in humans, were associated with plasma lipids and CHD in a prospective study of coronary heart disease (CHD) in healthy women.Three polymorphisms in the promoter region (−565C/T, −191G/C, and −17C/G) and two in the coding region (I883M and R1587K) were genotyped in the Nurses’ Health Study. During 8 years of follow-up, 249 incident cases of CHD were identified and matched to controls (1:2) on age and smoking.The I883M variant was associated with higher HDL-cholesterol levels among younger women. Nearly complete linkage disequilibrium was observed between −565C/T and −191G/C and their less common alleles predicted a lower risk of CHD (odds ratio of CHD per −191C allele: 0.8; 95% CI, 0.6–1.0). Neither the −17C/G SNP nor the 2 the coding polymorphisms were associated with risk of CHD. The −565C/T and the −191G/C variants were inversely associated with risk of CHD among healthy women, without pronounced effects on plasma lipids.
Journal: Atherosclerosis - Volume 195, Issue 1, November 2007, Pages e172–e180