کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2894584 1574726 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity
چکیده انگلیسی

BackgroundVisceral obesity (VO) is associated with an increased risk of cardiovascular disease. Elevated C-reactive protein (CRP) levels are associated with VO and cardiovascular disease. After exploring the relation between CRP and VO, we aimed to evaluate the VO independent relation between CRP and carotid atherosclerosis.Methods and resultsThe prevalence of inflammation was evaluated in 439 male subjects with VO without type 2 diabetes and manifest cardiovascular disease. Waist circumference significantly correlated with CRP (r: 0.20, p < 0.001). However, 18.2% of patients in the waist circumference group 94–102 had elevated CRP levels while 9.6% of patients in the waist circumference group >118 cm had low CRP levels. From the 439 subjects, 40 subjects were prospectively selected for MRI assessment of carotid atherosclerosis and visceral and subcutaneous adipose tissue distribution in a case–control setting matching for age and waist circumference. Twenty male subjects with age >50 years with CRP levels >2.5 mg/L (CRP+) were compared to 20 controls with CRP levels <1.8 mg/L (CRP−). Maximum vessel wall thickness in CRP+ was significantly higher both in the common carotid artery (15%, p < 0.01) and the bulb region (18%, p < 0.01). The distribution of fat in visceral and subcutaneous deposits was not significantly different between CRP+ and CRP−.ConclusionElevated CRP levels are associated with significantly increased maximum vessel wall thickness independent of VO and of MRI measured adipose tissue distribution, both in the common carotid artery and the carotid bulb.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 200, Issue 2, October 2008, Pages 417–423
نویسندگان
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