کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2894641 1172439 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C-terminal apolipoprotein E-derived peptide, Ep1.B, displays anti-atherogenic activity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
C-terminal apolipoprotein E-derived peptide, Ep1.B, displays anti-atherogenic activity
چکیده انگلیسی

ObjectiveApolipoprotein E (ApoE) is a lipid transport protein with expanded functions in cellular responses to tissue injury, immune regulation and cell growth. ApoE directs vascular changes that contribute to arterial protection as evidenced by the fact that isoforms of ApoE and ApoE deficiency correlate closely with accelerated plaque growth. The N-terminus of the ApoE protein has well-characterized functions, displaying lipid-binding and anti-atherogenic activity, whereas the function of the C-terminus is only partially defined. We have assessed the effects of a 14 amino acid C-terminal ApoE peptide, termed Ep1.B (239–252), on intimal neoplasia in animal models. This peptide is a fragment of a naturally processed peptide (236–252) of murine ApoE.Methods and resultsEp1.B injection reduced neointimal hyperplasia after vascular surgery in rats and mice. When given during early plaque progression in ApoE-deficient mice, Ep1.B injections also prevented plaque growth. Treatment with Ep1.B did not, however, reduce established plaque growth in older mice. Peptides with alanine substitution of amino acid 249, Ep1.N, and with complete sequence reversal, Ep1.R, did not consistently inhibit plaque growth.ConclusionA naturally processed C-terminal ApoE peptide, Ep1.B, has anti-atherogenic activity indicating a role for this naturally metabolized peptide in vascular wound healing and lipid homeostasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 194, Issue 1, September 2007, Pages 116–124
نویسندگان
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