کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2894648 1172439 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum paraoxonase-1 activity and concentration are influenced by human immunodeficiency virus infection
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Serum paraoxonase-1 activity and concentration are influenced by human immunodeficiency virus infection
چکیده انگلیسی

BackgroundHigher high-density lipoprotein concentrations are associated with a better disease course in HIV-infected patients. Paraoxonase-1, an enzyme contained within high-density lipoproteins, is thought to hydrolyse oxidised lipids. The aim of the present study was to investigate the relationships between HIV infection and the circulating activity and concentration of paraoxonase-1, and the concentration of high-density lipoproteins, apolipoprotein A-I and oxidised low-density lipoproteins.MethodsWe studied patients with HIV infection (n = 212) and healthy subjects (n = 409). In all the participants we measured the relevant biochemical and genetic variables. The statistical associations between these variables and paraoxonase-1 activity and concentration were assessed using multiple linear regression analysis.ResultsSerum paraoxonase-1 activity was decreased (P < 0.001) and its concentration was increased (P = 0.017) in HIV-patients compared to the controls. HIV infected patients had lower HDL-cholesterol and apolipoprotein A-I concentrations. Multivariate regression analysis showed that serum paraoxonase-1 activity was associated with the CD4+ T lymphocyte count (P < 0.05), apolipoprotein A-I (P < 0.001), and paraoxonase-1 genetic polymorphisms (P < 0.001). Paraoxonase-1 concentration was associated with that of serum β-2-microglobulin (P < 0.001).ConclusionsBoth, paraoxonase-1 activity and concentration were influenced by HIV-infection and these were related to alterations in HDL composition and the immunological status of the patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 194, Issue 1, September 2007, Pages 175–181
نویسندگان
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