کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2895116 1172450 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement factor H Y402H gene polymorphism, C-reactive protein, and risk of incident myocardial infarction, ischaemic stroke, and venous thromboembolism: A nested case–control study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Complement factor H Y402H gene polymorphism, C-reactive protein, and risk of incident myocardial infarction, ischaemic stroke, and venous thromboembolism: A nested case–control study
چکیده انگلیسی

ObjectivesAn exonic polymorphism (Y402H) in the complement factor H (CFH) gene, which locates within the binding sites for heparin and C-reactive protein, has recently been described and hypothesized to play an important role in atherothrombosis.MethodsWe, therefore, evaluated the CFH genetic variant Y402H amongst 685 Caucasian individuals who subsequently developed arterial or venous thrombotic event (incident myocardial infarction (MI), ischaemic stroke, or venous thromboembolism) and amongst 685 age- and smoking-matched Caucasian individuals who remained free of reported vascular disease during follow-up (controls) within the Physicians’ Health Study cohort.ResultsGenotype distribution for the polymorphism tested was in Hardy–Weinberg equilibrium in the control group. In contrast to expected results, we found no association of Y402H polymorphism with risk of atherothrombosis (adjusted: myocardial infarction, OR = 1.09, 95%CI 0.88–1.36, p = 0.43; ischaemic stroke, OR = 1.11, 95%CI 0.81–1.54, p = 0.52; venous thromboembolism, OR = 1.41, 95%CI 0.88–2.24, p = 0.15), nor with baseline plasma C-reactive protein levels [median (interquartile range) mg/L: YY, 1.39 (0.70–2.60); YH, 1.10 (0.57–2.16); HH, 1.00 (0.48–1.79); p = 0.14].ConclusionsIn this large, prospective cohort of apparently healthy Caucasian men, we found no association of the complement factor H Y402H gene polymorphism with risk of incident thromboembolic events, nor with baseline levels of C-reactive protein.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 187, Issue 2, August 2006, Pages 332–335
نویسندگان
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