کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2895378 1172458 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cardiac isoform of alpha-2 macroglobulin—A new biomarker for myocardial infarcted diabetic patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Cardiac isoform of alpha-2 macroglobulin—A new biomarker for myocardial infarcted diabetic patients
چکیده انگلیسی

Cardiac isoform of alpha-2 macroglobulin [cardiac α2M] has been shown to be an early marker in cardiac hypertrophy and left ventricular mass in humans. We, here, for the first time report its presence in myocardial infarcted humans and tried to explore the possibility of using this protein as a novel diagnostic marker for myocardial infarcted diabetic patients. A total of 260 samples were analyzed in this study for the presence of cardiac α2M. These include 55 patients of diabetic with post myocardial infarction [PMI], 45 diabetic patients without PMI, 60 patients of PMI alone and 100 controls without any ailments. Levels of cardiac α2M present in the sera of diabetic patients with PMI are significantly higher than that of normal human sera and diabetic patients without PMI but not with PMI alone group, suggesting this protein as a marker for PMI itself. However, our results reveal that cardiac α2M could be a valuable marker for the diagnosis of myocardial infarcted diabetic patients and differentiating them from diabetic patients without myocardial infarction by sandwich ELISA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 186, Issue 1, May 2006, Pages 173–176
نویسندگان
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