کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2898842 1173103 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Variability in fibrosis in tissue samples obtained during diaphragmatic and apical LVAD implantation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Variability in fibrosis in tissue samples obtained during diaphragmatic and apical LVAD implantation
چکیده انگلیسی

BackgroundHistopathologic study of left ventricular (LV) tissue can provide structural data on the heart at the time of left ventricular assist device (LVAD) implantation. We assessed the effect of cannula placement site (apical/diaphragmatic) and cardiomyopathy etiology (ischemic/nonischemic) on cardiac histopathologic changes.MethodsIn 77 heart failure patients, tissue was obtained from the standard apical cannula insertion site or the diaphragmatic surface site during implantation of the HeartMate II (n=53) or HeartWare (n=24) LVAD. Fibrosis and hypertrophy (cytoplasmic and nuclear diameter) were evaluated by computerized morphometry.ResultsThirty-two patients (27 men, 5 women; age, 57±15 years) underwent diaphragmatic implantation, and 45 (32 men, 13 women; age, 53±12 years) underwent apical implantation. The incidence of ischemic cardiomyopathy in the diaphragmatic and apical groups was 11/32 (34%) vs. 25/45 (56%) (P=.104). Overall, diaphragmatic tissue had less fibrosis than apical tissue (15.7±11.7% vs. 22.0±17.4%, P=.033), but both showed similar hypertrophic changes (cytoplasmic diameter, 39.0±10.3μm vs. 36.3±8.7μm, P=.141; nuclear diameter, 15.5±2.5μm vs. 14.8±3.0μm, P=.171). Likewise, in ischemic cardiomyopathy, apical samples showed more fibrosis than diaphragmatic samples (26.54±19.0% vs. 15.86±11.08%, P=.046) but similar hypertrophic changes (cytoplasmic diameter, 34.95±6.12μm vs. 37.48±12.07μm, P=.288; nuclear diameter, 14.66±2.69μm vs. 14.78±1.31μm, P=.451).ConclusionMyocardial histology results at the time of LVAD placement and their prognostic implications may be affected by inlet placement site and cardiomyopathy etiology. In this study, LV samples from apical implantation in ischemic cardiomyopathy patients were the most fibrotic. Thus, sampling site and cardiomyopathy etiology should be considered when interpreting LV samples obtained during LVAD implantation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cardiovascular Pathology - Volume 23, Issue 3, May–June 2014, Pages 121–125
نویسندگان
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