کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2899762 1173308 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treatment of OSA Reduces the Risk of Repeat Revascularization After Percutaneous Coronary Intervention
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Treatment of OSA Reduces the Risk of Repeat Revascularization After Percutaneous Coronary Intervention
چکیده انگلیسی

BACKGROUNDThe impact of OSA treatment with CPAP on percutaneous coronary intervention (PCI) outcomes remains largely unknown.METHODSBetween 2002 and 2012, we identified 390 patients with OSA who had undergone PCI. OSA was diagnosed through in-laboratory sleep studies and defined by an apnea-hypopnea index ≥ 5 events/h. The cohort was divided into three groups: (1) moderate-severe OSA successfully treated with CPAP (n = 128), (2) untreated moderate-severe OSA (n = 167), and (3) untreated mild OSA (n = 95). Main outcomes included repeat revascularization, major adverse cardiac events (MACEs) (ie, death, nonfatal myocardial infarction, repeat revascularization), and major adverse cardiac or cerebrovascular events (MACCEs). The median follow-up period was 4.8 years (interquartile range, 3.0-7.1).RESULTSThe untreated moderate-severe OSA group had a higher incidence of repeat revascularization than the treated moderate-severe OSA group (25.1% vs 14.1%,P= .019). There were no differences in mortality (P= .64), MACE (P= .33), and MACCE (P= .76) among the groups. In multivariate analysis adjusted for potential confounders, untreated moderate-severe OSA was associated with increased risk of repeat revascularization (hazard ratio, 2.13; 95% CI, 1.19-3.81;P= .011).CONCLUSIONSUntreated moderate-severe OSA was independently associated with a significant increased risk of repeat revascularization after PCI. CPAP treatment reduced this risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 147, Issue 3, March 2015, Pages 708–718
نویسندگان
, , , , , ,