کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2903573 1173394 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship Between Pulmonary Emphysema and Osteoporosis Assessed by CT in Patients With COPD
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Relationship Between Pulmonary Emphysema and Osteoporosis Assessed by CT in Patients With COPD
چکیده انگلیسی

BackgroundOsteoporosis is one of the important systemic features of COPD. Although COPD itself is regarded as one risk factor for osteoporosis, the relationship between the extent of emphysema and reduced bone density is still unclear. Our first aim was therefore to measure vertebral bone density and the percentage of low-attenuation area (LAA%) in the lungs using chest CT scans in COPD patients. Our second aim was to investigate the relationships among CT scan measurements, anthropometric parameters, and pulmonary function.MethodsChest CT scans and pulmonary function tests were performed in 65 male patients with COPD. Using CT images, the CT scan density of the thoracic and lumbar vertebrae (T4, T7, T10, and L1) and the LAA% were measured quantitatively, and their correlations were analyzed.ResultsLinear regression analyses revealed that LAA% had a significant negative correlation with bone mineral density (BMD) [r = −0.522]. In addition, multiple regression analysis showed that only LAA% and body mass index (BMI) were predictive of BMD among age, BMI, smoking index, FEV1, arterial blood gas, and LAA%.ConclusionsThe extent of pulmonary emphysema significantly correlated with reduced bone density. Our study suggested that COPD itself could be a risk factor for osteoporosis and that chest CT scanning is useful for the management of COPD as a systemic disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 134, Issue 6, December 2008, Pages 1244–1249
نویسندگان
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