کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2903896 1173399 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Donepezil Improves Obstructive Sleep Apnea in Alzheimer Disease : A Double-Blind, Placebo-Controlled Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Donepezil Improves Obstructive Sleep Apnea in Alzheimer Disease : A Double-Blind, Placebo-Controlled Study
چکیده انگلیسی

BackgroundThere is an association between Alzheimer disease and sleep-disordered breathing. Donepezil is the drug most frequently used to treat cognitive symptoms in Alzheimer disease. This study evaluates the effects of donepezil on obstructive sleep apnea in patients with Alzheimer disease.MethodsRandomized, double-blind, placebo-controlled design. Twenty-three patients with mild-to-moderate Alzheimer disease and apnea-hypopnea index (AHI) > 5/h were allocated to two groups: donepezil treated (n = 11) and placebo treated (n = 12). Polysomnography and cognitive evaluation using Alzheimer disease assessment scale-cognitive (ADAS-cog) subscale were performed at baseline and after 3 months. Cognitive and sleep data were analyzed using analysis of variance.ResultsAHI and oxygen saturation improved significantly after donepezil treatment compared to baseline and placebo (p < 0.05). Rapid eye movement (REM) sleep duration increased after donepezil treatment (p < 0.05). ADAS-cog scores improved after donepezil treatment, although they did not correlate with REM sleep increase and sleep apnea improvement (p < 0.01).ConclusionsDonepezil treatment improved AHI and oxygen saturation in patients with Alzheimer disease. Treatment also increased REM sleep duration and reduced ADAS-cog scores.Trial registrationClinicalTrials.gov Identifier: NCT00480870.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 133, Issue 3, March 2008, Pages 677–683
نویسندگان
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