کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2907062 | 1173488 | 2005 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Interleukin-13 and Interleukin-5 in Induced Sputum of Eosinophilic Bronchitis : Comparison With Asthma Interleukin-13 and Interleukin-5 in Induced Sputum of Eosinophilic Bronchitis : Comparison With Asthma](/preview/png/2907062.png)
Study objectivesExperimental studies on asthma have indicated that interleukin (IL)-13 induces airway hyperreactivity (AHR). However, it remains unproven that IL-13 is responsible for AHR in asthmatic patients. Eosinophilic bronchitis (EB) shows normal airway responsiveness despite eosinophilic airway inflammation of severity similar to that of asthma. This study evaluated the role of IL-13 in asthma by comparing the sputum IL-5 and IL-13 levels in both groups.MethodsComparisons between asthma and EB would clarify the role of IL-13 in AHR. IL-5 and IL-13 were assayed in the sputum and culture supernatants of peripheral blood mononuclear cells (PBMCs) from 22 asthmatic patients, 12 EB patients, and 11 healthy control subjects.ResultsIL-13 levels were higher in the asthmatic patients than in the EB patients or healthy control subjects (p = 0.001). IL-5 levels were similar in the asthmatic patients and EB patients, who had significantly higher levels than those of healthy control subjects. Sputum IL-13, but not IL-5, is inversely correlated with the provocative concentration of a substance causing a 20% fall in FEV1 for methacholine in asthmatic patients (r = −0.502; p = 0.017). IL-13 production by PBMCs was significantly higher in asthmatic patients than in EB patients (p = 0.015), but the levels between EB patients and healthy control subjects was comparable.ConclusionThe results of the present study indicate that IL-13 is related to AHR in asthmatic patients.
Journal: Chest - Volume 128, Issue 4, October 2005, Pages 1921–1927