Metabolic syndrome in first degree relatives of patients with type 2 diabetes: Incidence and risk factors

AimsFirst degree relatives (FDRs) of people with type 2 diabetes are at greater cardiovascular and diabetes risk. It is not known whether they are also at greater risk of metabolic syndrome (MetS). The objectives of present study were to assess the incidence of and risk factors for the development of MetS in FDRs of patients with type 2 diabetes.MethodsA total of 3217 (842 men and 2375 women) FDRs of consecutive patients with type 2 diabetes aged 30–70 years in 2003–2005 were followed through 2010. At baseline participants underwent a standard 75 g 2-h standard OGTT and HbA1c measurements. MetS was defined by the NCEP-ATP III. The study group consisted of 734 participants without MetS and history of known diabetes at baseline and had at least one subsequent review in mean (SD) follow-up period of 5.5 (1.2) years.ResultsThe prevalence of MetS was 35.8% (95% CI: 34.2, 37.5). The incidence of MetS was 4.3% (95% CI: 3.7, 4.9) (4.6% men and 4.2% women) per year. Multivariate analysis revealed that impaired glucose tolerance (IGT) (RR 1.89 (95% CI: 1.28, 2.79)), impaired fasting glucose (IFG) (RR 1.39 (95% CI: 1.10, 1.73)) and lower HDL (RR 1.34 (95% CI: 1.12, 1.60)) were associated with MetS.ConclusionsThe findings of this study illustrate for the first time the incidence of MetS in FDRs of patients with type 2 diabetes in Iran. Risk of MetS may increases with IGT, IFG and lower HDL.

► We illustrate for the first time the incidence of metabolic syndrome in relatives of patients with type 2 diabetes in Iran.
► Risk of metabolic syndrome may increases with impaired glucose tolerance.
► Risk of metabolic syndrome may increases with impaired fasting glucose.
► Risk of metabolic syndrome may increases with lower HDL.