کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2910638 1175021 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnostic value of N-terminal pro-brain natriuretic peptide levels in pediatric patients with ventricular septal defect
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Diagnostic value of N-terminal pro-brain natriuretic peptide levels in pediatric patients with ventricular septal defect
چکیده انگلیسی

Background and aimThe plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) can reflect the cardiac functions in patients with cardiac diseases. Our aim is to assess the value of NT-proBNP in the diagnosis of heart failure and evaluation of cardiac functions in pediatric patients with ventricular septal defect (VSD).Patients and methodThe study comprised 40 children with VSD (mean age 12 ± 5 months) and 20 healthy children as a control group. Detailed echocardiographic examination was performed and the level of NT-proBNP level was measured.ResultsThe plasma level of NT-proBNP was significantly higher in patients with VSD than in control subjects (P < 0.05). Also, it was significantly increased in VSD patients with congestive heart failure (CHF) than those without heart failure (P < 0.05). Moreover, NT-proBNP level increased with increasing severity of clinical symptoms. There were positive correlations between NT-proBNP level and left ventricular end diastolic diameter, left ventricular end systolic diameter, estimated systolic pulmonary artery pressure and VSD size and negative correlations with ejection fraction (EF) and fractional shortening (FS) in VSD patients with or without heart failure. The plasma levels of NT-proBNP with cutoff value of 101 fmol/ml (854 pg/ml), predicted CHF with a sensitivity of 90.0%, specificity of 80%, and area under ROC curve was 0.980.ConclusionNT-proBNP level is a good marker of disease severity and correlates with echocardiographic measurements and clinical symptoms in pediatric patients with VSD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Egyptian Heart Journal - Volume 64, Issue 4, December 2012, Pages 241–246
نویسندگان
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