کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2913531 1575493 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deactivation of Sodium Tetradecyl Sulphate Injection by Blood Proteins
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Deactivation of Sodium Tetradecyl Sulphate Injection by Blood Proteins
چکیده انگلیسی

ObjectivesThe aim of this work was to quantify the volume of blood required to deactivate 1 ml of 3% sodium tetradecyl sulphate (STS).DesignA series of experiments were performed where the concentration of STS remaining in a stock solution was measured after adding increasing volumes of blood protein solutions.Materials and methodsIncreasing volumes of bovine serum albumin, bovine erythrocytes and a mixture of both was added to a stock solution of STS. The BP manual titration method was used to measure the assay of the remaining STS.ResultsThe method was reproducible and increasing volumes of blood protein lowered the STS concentration in a linear fashion. Approximately 2 ml of a 4% blood protein solution deactivates 1 ml of 3% STS, which means approximately 0.5 ml of whole blood will deactivate 1 ml of 3% STS.ConclusionsSodium tetradecyl sulphate injection is deactivated by a relatively small volume of blood. The practical implication is that changes in technique to reduce the blood volume in larger veins and to introduce fresh aliquots of sclerosant along the length of the vein could improve the efficacy of sclerotherapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Vascular and Endovascular Surgery - Volume 41, Issue 4, April 2011, Pages 521–525
نویسندگان
,