کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2913704 1575482 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Critical Limb Ischaemia: Initial Treatment and Predictors of Amputation-free Survival
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Critical Limb Ischaemia: Initial Treatment and Predictors of Amputation-free Survival
چکیده انگلیسی

ObjectivesTo evaluate initial treatment and risk factors for amputation-free survival in patients with critical limb ischaemia (CLI).DesignProspective clinical cohort study at a single vascular surgical centre in Germany.MethodsData on 104 consecutive patients (115 ischaemic limbs) presenting with their first episode of CLI were collected prospectively over a 3-year period. Initial treatment was classified as conservative therapy, intervention, surgery, or major amputation. Patient co-morbidities were assessed by uni- and multivariate analysis to determine risk factors for limb salvage, survival and amputation-free survival.ResultsIndications for treatment were rest pain in 27 (23.5%) and tissue loss in 88 (76.5%) limbs. Revascularisation was attempted in 65% of all limbs: 45% by intervention and 55% by surgery. In 9% primary amputation was necessary and 22% received conservative therapy. Median follow-up was 28 months (1–42). The 3-year limb salvage, patient survival, and amputation-free survival rates were 73%, 41%, and 31%, respectively. Diabetes, cardiac disease and renal insufficiency were associated with poor survival. Combined cardiac and renal disease adversely affected amputation-free survival (HR, 3.68; 95% CI, 1.51–8.94; P < 0.001).ConclusionsAt least two third of all patients presenting with CLI can be offered some type of direct revascularisation. In patients with major cardiac disease and renal insufficiency, a poor outcome in terms of amputation-free survival is to be anticipated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Vascular and Endovascular Surgery - Volume 43, Issue 1, January 2012, Pages 55–61
نویسندگان
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