کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2922811 1175856 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spontaneous electrocardiogram alterations predict ventricular fibrillation in Brugada syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Spontaneous electrocardiogram alterations predict ventricular fibrillation in Brugada syndrome
چکیده انگلیسی

BackgroundPatients with Brugada syndrome (BS) often have spontaneous changes in their electrocardiogram (ECG).ObjectiveTo evaluate the significance of ECG alterations, we investigated the relationships between the ECG and the occurrence of ventricular fibrillation (VF) in both patients and an experimental model of BS.MethodsIn study 1, we evaluated ECG alterations in BS patients with (VF+, n = 33) and without (VF−, n = 41) spontaneous VF. We defined type 0 ECG as coved-type ST elevation without a negative T wave, which represents the existence of loss-of-dome (LOD) type action potentials (APs). In study 2, we optically mapped epicardial APs and recorded transmural ECGs in 34 canine right ventricular tissues with a drug-induced BS model by a combination of pinacidil and pilsicainide.ResultsIn study 1, changes in ST level ≥0.2 mV were more frequent in the VF+ group than in the VF− group (P <.01). Spontaneous ECG alterations and appearances of types 1 and 0 ECGs were more frequent in the VF+ group than in the VF− group (P <.01). In study 2, BS model with spike-and-dome (SAD) epicardial APs exhibited type 1 ECG. Deepening of the phase 1 notch of the APs induced heterogeneous conversion of the APs (SAD→LOD) and resulted in ECG conversion from type 1 to type 0. Significant AP heterogeneity often appeared during AP alterations and initiated phase 2 reentry. Tissues having ventricular tachycardia (VT; n = 20) had more frequent alterations in APs and ECG than in tissues without VT (n = 14; P <.01).ConclusionECG alterations, especially conversion between types 0 and 1, are associated with significant AP heterogeneity that can initiate VF in BS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 8, Issue 7, July 2011, Pages 1014–1021
نویسندگان
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