کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2923494 | 1175875 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Bidirectional ventricular tachycardia: Ping pong in the His–Purkinje system Bidirectional ventricular tachycardia: Ping pong in the His–Purkinje system](/preview/png/2923494.png)
BackgroundBidirectional ventricular tachycardia (BVT), which is characterized by an alternating beat-to-beat ECG QRS axis, is a rare but intriguing arrhythmia associated with digitalis toxicity, familial catecholaminergic polymorphic ventricular tachycardia (CPVT), and several other conditions that predispose cardiac myocytes to delayed afterdepolarizations (DADs) and triggered activity. Evidence from human and animal studies attributes BVT to alternating ectopic foci originating from the distal His–Purkinje system in the left and/or right ventricle, respectively.ObjectiveThe purpose of this study was to evaluate a simple “ping pong” model of reciprocating bigeminy to explain BVT.MethodsWe constructed a two-dimensional anatomic model of the rabbit ventricles with a simplified His–Purkinje system, in which different sites in the His–Purkinje system had different heart rate thresholds for DAD-induced bigeminy.ResultsWhen the heart rate exceeded the threshold for bigeminy at the first site in the His–Purkinje system, ventricular bigeminy developed, causing the heart rate to accelerate and exceed the threshold for bigeminy at the second site. Thus, the triggered beat from the first site induced a triggered beat from the second site. The triggered beat from the second site next reciprocated by inducing a triggered beat from the first site, and so forth. Bigeminy from two sites produced BVT, and that from three or more sites produced polymorphic VT.ConclusionThis “ping pong” mechanism of reciprocating bigeminy readily produces the characteristic ECG pattern of BVT and its degeneration to polymorphic VT if additional sites develop bigeminy.
Journal: Heart Rhythm - Volume 8, Issue 4, April 2011, Pages 599–605