کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2923613 1175880 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanoelectrical coupling enhances initiation and affects perpetuation of atrial fibrillation during acute atrial dilation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Mechanoelectrical coupling enhances initiation and affects perpetuation of atrial fibrillation during acute atrial dilation
چکیده انگلیسی

BackgroundAcute atrial dilation increases the susceptibility to atrial fibrillation (AF). However, the mechanisms by which atrial stretch may contribute to the initiation and perpetuation of AF remain to be determined.ObjectiveThe purpose of this study was to use a novel multiscale model of atrial electromechanics and mechanoelectrical feedback to test the hypothesis that acute stretch increases vulnerability to AF by heterogeneous activation of stretch-activated channels.MethodsHuman atria were represented by a triangular mesh obtained from magnetic resonance imaging data. Atrial trabecular bundle structure was incorporated by varying thicknesses of the atrial wall. Atrial membrane behavior was modeled by the Courtemanche-Ramirez-Nattel model with the addition of a nonselective stretch-activated cation current (Isac). Mechanical behavior was modeled by a series elastic, a contractile, and a parallel elastic element in which contractile force was related to intracellular concentration of free calcium and sarcomere length.ResultsAcute atrial dilation was simulated by increasing stretch throughout the atrial wall. Stimulation near the pulmonary vein ostia at an interval of 600 ms induced AF at an overall stretch ratio of 1.10. Initiation and perpetuation of AF in our model were related to increased dispersion of effective refractory period, conduction slowing, and local conduction block, all related to heterogeneous activation of Isac. Upon local contraction, mechanoelectrical coupling affects perpetuation of AF by temporarily changing local excitability.ConclusionDuring acute atrial dilation, heterogeneous activation of Isac enhances initiation and can affect perpetuation of AF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 8, Issue 3, March 2011, Pages 429–436
نویسندگان
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