کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2928852 1576139 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A literature review to evaluate the economic value of ranolazine for the symptomatic treatment of chronic angina pectoris
ترجمه فارسی عنوان
بررسی ادبیات برای ارزیابی ارزش اقتصادی رانولازین برای درمان علائم آنژیوگرافی مزمن
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• Ranolazine, added to SOC, is cost-effective in EU and US for the treatment of CSA.
• It improves QoL, reduces revascularization rates with a modest increase in costs.
• Ranolazine remained cost–effective in all the DSAs.
• Limited evidence related to the economic value of ranolazine was observed.
• Health economic models with longer time horizons are recommended.

To conduct a systematic review of the evidence regarding the economic value of ranolazine relative to standard-of-care (SOC) for the treatment of symptomatic chronic stable angina (CSA).Electronic databases were searched using relevant keywords. The identified studies were independently reviewed by two investigators against pre-determined inclusion and exclusion criteria. Their data were extracted using a relevant form and consequently were synthesized. Studies were also evaluated using the Quality of Health Economic Studies scale. The main outcomes considered were the cost and effectiveness for each comparator and the incremental cost per quality-adjusted-life year (QALY) gained.Six studies were included in the review. Five of these assessed the cost-utility of ranolazine added to SOC, compared to SOC alone, using decision trees or Markov models whereas one was a retrospective cost evaluation study. The analysis was conducted from a payer perspective in five studies and from a societal perspective in one study with the time horizon varying between six months and a year. The incremental cost-effectiveness ratio (ICER), ranged from €4000 to €15,000 per QALY gained. Ranolazine appears to be dominant or cost-effective, mainly due to its ability to decrease angina-related hospitalizations and also due to a marginal improvement in quality of life. The acquisition cost of ranolazine was the variable with the greatest impact upon the ICER.The existing evidence, although limited, indicates that ranolazine may be a dominant or cost-effective therapy option, for the treatment of patients with symptomatic CSA. Further research is required to evaluate the cost-effectiveness of ranolazine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 211, 15 May 2016, Pages 105–111
نویسندگان
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