کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2941985 1177095 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drug-Eluting Stents Versus Bare-Metal Stents in Saphenous Vein Graft Interventions : A Systematic Review and Meta-Analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Drug-Eluting Stents Versus Bare-Metal Stents in Saphenous Vein Graft Interventions : A Systematic Review and Meta-Analysis
چکیده انگلیسی

ObjectivesWe sought to review the published data and perform a meta-analysis to reach robust conclusions in the comparison between bare-metal stents (BMS) and drug-eluting stents (DES) in saphenous vein graft (SVG) percutaneous coronary interventions (PCIs).BackgroundDrug-eluting stents are superior to BMS in reducing major adverse cardiac events (MACE) after PCI in native coronary arteries. However, studies comparing BMS with DES in PCI of SVG have had mixed results, probably due to smaller numbers and the nonrandomized nature of most of them.MethodsThe published reports search identified 4 randomized controlled trials and 19 cohort studies comparing BMS with DES in SVG interventions. Clinical end point data were abstracted and analyzed in aggregate and in subgroup analyses with random-effects model.ResultsPatients receiving DES had a lower risk of mortality (odds ratio [OR]: 0.75; confidence interval [CI]: 0.59 to 0.96), target lesion revascularization (TLR) (OR: 0.57; CI: 0.40 to 0.82), target vessel revascularization (TVR) (OR: 0.56; CI: 0.40 to 0.77), and MACE (OR: 0.61; CI: 0.42 to 0.79). Drug-eluting stent use resulted in a significant absolute risk reduction in TLR (−0.07; CI: −0.11 to −0.03), TVR (−0.10; CI: −0.15 to −0.05), and MACE (−0.12; CI: −0.18 to −0.06). There was no significant difference between the groups in recurrent myocardial infarction (OR: 0.99; CI: 0.65 to 1.51) or stent thrombosis (OR: 0.78; CI: 0.40 to 1.52).ConclusionsIn this meta-analysis comparing DES with BMS use in PCI of SVG lesions, DES use was associated with improved mortality, MACE, TLR, and TVR. There was no evidence of increased risk of myocardial infarction or stent thrombosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: JACC: Cardiovascular Interventions - Volume 3, Issue 12, December 2010, Pages 1262–1273
نویسندگان
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