کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2943542 1577053 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Imaging Systemic Inflammatory Networks in Ischemic Heart Disease
ترجمه فارسی عنوان
شبکه های التهابی سیستمیک تصویر برداری در بیماری های قلبی ایسکمیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

While acute myocardial infarction mortality declines, patients continue to face reinfarction and/or heart failure. The immune system, which intimately interacts with healthy and diseased tissues through resident and recruited leukocytes, is a central interface for a global host response to ischemia. Pathways that enhance the systemic leukocyte supply may be potential therapeutic targets. Pre-clinically, imaging helps to identify immunity’s decision nodes, which may serve as such targets. In translating the rapidly-expanding pre-clinical data on immune activity, the difficulty of obtaining multiple clinical tissue samples from involved organs is an obstacle that whole-body imaging can help overcome. In patients, molecular and cellular imaging can be integrated with blood-based diagnostics to assess the translatability of discoveries, including the activation of hematopoietic tissues after myocardial infarction, and serve as an endpoint in clinical trials. In this review, we discuss these concepts while focusing on imaging immune activity in organs involved in ischemic heart disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 65, Issue 15, 21 April 2015, Pages 1583–1591
نویسندگان
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