کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2946914 1577190 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantification of Absolute Myocardial Perfusion in Patients With Coronary Artery Disease : Comparison Between Cardiovascular Magnetic Resonance and Positron Emission Tomography
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Quantification of Absolute Myocardial Perfusion in Patients With Coronary Artery Disease : Comparison Between Cardiovascular Magnetic Resonance and Positron Emission Tomography
چکیده انگلیسی

ObjectivesThe aim of this study was to compare fully quantitative cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) myocardial perfusion and myocardial perfusion reserve (MPR) measurements in patients with coronary artery disease (CAD).BackgroundAbsolute quantification of myocardial perfusion and MPR with PET have proven diagnostic and prognostic roles in patients with CAD. Quantitative CMR perfusion imaging has been established more recently and has been validated against PET in normal hearts. However, there are no studies comparing fully quantitative CMR against PET perfusion imaging in patients with CAD.MethodsForty-one patients with known or suspected CAD prospectively underwent quantitative 13N-ammonia PET and CMR perfusion imaging before coronary angiography.ResultsThe CMR-derived MPR (MPRCMR) correlated well with PET-derived measurements (MPRPET) (r = 0.75, p < 0.0001). MPRCMR and MPRPET for the 2 lowest scoring segments in each coronary territory also correlated strongly (r = 0.79, p < 0.0001). Absolute CMR perfusion values correlated significantly, but weakly, with PET values both at rest (r = 0.32; p = 0.002) and during stress (r = 0.37; p < 0.0001). Area under the receiver-operating characteristic curve for MPRPET to detect significant CAD was 0.83 (95% confidence interval: 0.73 to 0.94) and for MPRCMR was 0.83 (95% confidence interval: 0.74 to 0.92). An MPRPET ≤1.44 predicted significant CAD with 82% sensitivity and 87% specificity, and MPRCMR ≤1.45 predicted significant CAD with 82% sensitivity and 81% specificity.ConclusionsThere is good correlation between MPRCMR and MPRPET. For the detection of significant CAD, MPRPET and MPRCMR seem comparable and very accurate. However, absolute perfusion values from PET and CMR are only weakly correlated; therefore, although quantitative CMR is clinically useful, further refinements are still required.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 60, Issue 16, 16 October 2012, Pages 1546–1555
نویسندگان
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