کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2950924 | 1577453 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Early Breast Cancer Therapy and Cardiovascular Injury Early Breast Cancer Therapy and Cardiovascular Injury](/preview/png/2950924.png)
Although recent advances in curative-intent therapies are beginning to produce significant survival gains in early breast cancer, these improvements may ultimately be attenuated by increased risk of long-term cardiovascular mortality. This paper reviews emerging evidence on the cardiovascular effects of breast cancer adjuvant therapy and proposes a new entity that we have labeled the “multiple-hit” hypothesis. The evidence that lifestyle modification, especially exercise therapy, may mitigate these adverse effects is also reviewed. These issues are of considerable practical importance for cardiovascular clinicians, as identification and intervention in those at high risk for cardiovascular complications may reduce a major cause of mortality in women with early breast cancer.
Journal: Journal of the American College of Cardiology - Volume 50, Issue 15, 9 October 2007, Pages 1435–1441