کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2951201 1577320 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maintenance of Sinus Rhythm and Survival in Patients With Heart Failure and Atrial Fibrillation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Maintenance of Sinus Rhythm and Survival in Patients With Heart Failure and Atrial Fibrillation
چکیده انگلیسی

ObjectivesThe goal of this study was to evaluate the relationship between the presence of sinus rhythm and outcomes in patients with a history of congestive heart failure (CHF) and atrial fibrillation (AF).BackgroundThe value of sinus rhythm maintenance in patients with AF and heart failure (HF) is uncertain.MethodsA total of 1,376 patients with AF, ejection fraction ≤35%, and heart failure symptoms were randomized to a rhythm- or rate-control strategy. Detailed efficacy analyses were used to evaluate the independent effects of treatment strategy and the presence of sinus rhythm on cardiovascular outcomes.ResultsOverall, 445 (32%) patients died and 402 (29%) experienced worsening HF. The rhythm-control strategy was not predictive of cardiovascular mortality (hazard ratio [HR]: 0.90, 95% confidence interval [CI]: 0.70 to 1.16; p = 0.41), all-cause death (HR: 0.86, 95% CI: 0.69 to 1.08; p = 0.19), or worsening HF (HR: 0.86, 95% CI: 0.68 to 1.10; p = 0.23). In analyses devised to isolate the effect of underlying rhythm, sinus rhythm was not associated with cardiovascular mortality [HR: 1.22, 95% CI: 0.80 to 1.87; p = 0.35), total mortality [HR: 1.11, 95% CI: 0.78 to 1.58; p = 0.57), or worsening HF [HR: 0.62, 95% CI: 0.37 to 1.02; p = 0.059).ConclusionsA rhythm-control strategy or the presence of sinus rhythm are not associated with better outcomes in patients with AF and CHF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 55, Issue 17, 27 April 2010, Pages 1796–1802
نویسندگان
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