کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2951945 1577497 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of Clopidogrel With and Without Eptifibatide on Tumor Necrosis Factor-Alpha and C-Reactive Protein Release After Elective Stenting : Results From the CLEAR PLATELETS 1b Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effect of Clopidogrel With and Without Eptifibatide on Tumor Necrosis Factor-Alpha and C-Reactive Protein Release After Elective Stenting : Results From the CLEAR PLATELETS 1b Study
چکیده انگلیسی

ObjectivesThis study was performed to compare the effects of antiplatelet regimens on early inflammation and cardiac marker release after elective stenting.BackgroundFew data exist regarding the comparative effects of specific antiplatelet regimens on early inflammation marker release after stenting.MethodsIn a 2 × 2 factorial randomized investigation, patients undergoing stenting were treated with either clopidogrel alone (300 mg or 600 mg; n = 60) or clopidogrel with eptifibatide (n = 60). Platelet aggregation (5 and 20 μM adenosine diphosphate [ADP]), ADP-stimulated expression of active glycoprotein (GP) IIb/IIIa, and platelet-bound P-selectin, tumor necrosis factor (TNF)-α, C-reactive protein (CRP), and cardiac markers were measured.ResultsCompared with a strategy of clopidogrel alone, clopidogrel + eptifibatide reduced the release of cardiac markers. A marked reduction in platelet aggregation and active GP IIb/IIIa expression (p ≤ 0.001) with clopidogrel + eptifibatide was associated with a decrease in CRP and TNF-α release (p ≤ 0.001).ConclusionsA strategy of clopidogrel with GP IIb/IIIa blockade resulted in superior inhibition of inflammation and cardiac marker release, which was accompanied by superior platelet inhibition immediately after percutaneous coronary intervention compared with a strategy of clopidogrel alone. The mechanistic and clinical implications of attenuated periprocedural inflammation and myocardial necrosis with a strategy of GP IIb/IIIa inhibition warrant further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 48, Issue 11, 5 December 2006, Pages 2186–2191
نویسندگان
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