کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2954376 1577527 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of Fluvastatin on the Carotid Arterial Media as Assessed by Integrated Backscatter Ultrasound Compared With Pulse-Wave Velocity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effects of Fluvastatin on the Carotid Arterial Media as Assessed by Integrated Backscatter Ultrasound Compared With Pulse-Wave Velocity
چکیده انگلیسی

ObjectivesOur goal is to show the effectiveness of fluvastatin in reducing arterial sclerosis using integrated backscatter (IB) values rather than depending on the pulse-wave velocity (PWV) and stiffness beta.BackgroundAtherosclerotic changes consist of two components: atherosis as a structural change and sclerosis as a functional change; IB ultrasound of carotid media was useful for assessment of arterial sclerosis.MethodsWe measured IB values in the media of 40 segments of carotid arteries in 40 patients with hyperlipidemia before and after statin therapy or diet for 12 months (fluvastatin [F group] 40 mg/day, n = 20; control [C group]: diet, n = 20). Pulse-wave velocity, intima-media thickness, and stiffness beta were measured at the same time.ResultsAt baseline, IB values correlated with PWV (r = 0.71, p < 0.001) and stiffness beta (r = 0.47, p = 0.002) in 40 patients with hyperlipidemia. Integrated backscatter values did not change in the C group but decreased in the F group (from 12.3 ± 2.1 dB to 11.3 ± 2.1 dB, p = 0.002). Also, PWV increased in the C group (from 1,728 ± 687 cm/s to 1,771 ± 716 cm/s, p = 0.021) but decreased in the F group (from 1,848 ± 582 cm/s to 1,768 ± 549 cm/s, p = 0.012). Stiffness beta decreased in the F group (from 14.0 ± 3.9 to 12.1 ± 3.5, p = 0.002).ConclusionsStatin therapy with fluvastatin improved arterial sclerosis as assessed by IB values.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 46, Issue 11, 6 December 2005, Pages 2031–2037
نویسندگان
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