کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2958262 1405927 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum Bicarbonate in Acute Heart Failure: Relationship to Treatment Strategies and Clinical Outcomes
ترجمه فارسی عنوان
بی کربنات سرم در نارسایی حاد قلب: رابطه با استراتژی های درمان و نتایج بالینی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• Elevated serum bicarbonate is a common observation in acute heart failure (AHF) patients.
• In AHF, bicarbonate increased with diuretics but decreased with ultrafiltration.
• Bicarbonate change was not associated with clinical signs of decongestion.
• Adequate decongestion is a key goal in the treatment of patients with AHF.
• Modest increases in bicarbonate should not prompt decrease or cessation of diuresis.

BackgroundThough commonly noted in clinical practice, it is unknown if decongestion in acute heart failure (AHF) results in increased serum bicarbonate.Methods and ResultsFor 678 AHF patients in the DOSE-AHF, CARRESS-HF, and ROSE-AHF trials, we assessed change in bicarbonate (baseline to 72–96 hours) according to decongestion strategy, and the relationship between bicarbonate change and protocol-defined decongestion. Median baseline bicarbonate was 28 mEq/L. Patients with baseline bicarbonate ≥28 mEq/L had lower ejection fraction, worse renal function and higher N-terminal pro–B-type natriuretic peptide than those with baseline bicarbonate <28 mEq/L. There were no differences in bicarbonate change between treatment groups in DOSE-AHF or ROSE-AHF (all P > .1). In CARRESS-HF, bicarbonate increased with pharmacologic care but decreased with ultrafiltration (median +3.3 vs −0.9 mEq/L, respectively; P < .001). Bicarbonate change was not associated with successful decongestion (P > .2 for all trials).ConclusionsIn AHF, serum bicarbonate is most commonly elevated in patients with more severe heart failure. Despite being used in clinical practice as an indicator for decongestion, change in serum bicarbonate was not associated with significant decongestion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 22, Issue 9, September 2016, Pages 738–742
نویسندگان
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