کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2958299 1178285 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationships Among Cognitive Function and Cerebral Blood Flow, Oxidative Stress, and Inflammation in Older Heart Failure Patients
ترجمه فارسی عنوان
ارتباط بین عملکرد شناختی و جریان خون مغزی، استرس اکسیداتیو و التهاب در بیماران نارسایی قلبی قدیمی
کلمات کلیدی
نارسایی قلبی، شناختی، استرس اکسیداتیو، آنتی اکسیدان ها، التهاب سرعت جریان خون
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


• Power of Attention composite score is impaired in older heart failure patients.
• Cognitive impairments are related to reduced cerebral blood flow velocity and lower coenzyme Q10.
• Diacron-reactive oxygen metabolites are an additional oxidative stress measure elevated in elderly heart failure patients.

BackgroundThe mechanisms for cognitive impairment in heart failure (HF) are unclear. We investigated the relative contributions of cerebral blood flow velocity (BFV), oxidative stress, and inflammation to HF-associated cognitive impairment.Methods and ResultsThirty-six HF patients (≥60 years) and 40 healthy controls (68 ± 7 vs 67 ± 5 years, P > .05; 69% vs 50% male, P > .05) completed the Cognitive Drug Research computerized assessment battery and Stroop tasks. Common carotid (CCA) and middle cerebral arterial BFV were obtained by transcranial Doppler. Blood samples were collected for oxidant (diacron-reactive oxygen metabolites; F2-isoprostanes), antioxidant (coenzyme Q10; CoQ10), and inflammatory markers (high-sensitivity C-reactive protein). Compared with controls, patients exhibited impaired attention (Cognitive Drug Research's Power of Attention domain, congruent Stroop) and executive function (incongruent Stroop). Multiple regression modeling showed that CCA-BFV and CoQ10 but not group predicted performance on attention and executive function. Additionally, in HF patients, CCA-BFV and CoQ10 (β = −0.34 vs β = −0.35) were significant predictors of attention, and CCA-BFV (β = −0.34) was a predictor of executive function.ConclusionsPower of Attention and executive function is impaired in older HF patients, and reduced CCA-BFV and CoQ10 are associated with worse cognition. Interventions addressing these mechanisms may improve cognition in older HF patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 22, Issue 7, July 2016, Pages 548–559
نویسندگان
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