کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2961809 1178403 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Effect of Statins in Heart Failure: Beyond its Cholesterol-Lowering Effect
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The Effect of Statins in Heart Failure: Beyond its Cholesterol-Lowering Effect
چکیده انگلیسی

BackgroundStatins known as 3-hydroxyl-3-methyl-glutaryl-coenzyme A (HMG-CoA) are designed to lower plasma cholesterol levels. They are used to treat hypercholesterolemia, ischemic heart disease patients, heart transplant recipients, in prevention of Alzheimer's dementia, multiple sclerosis, and have also been shown to reduce cancer risk.Methods and ResultsThe idea of statin treatment in chronic heart failure is not well established. It has been shown to be beneficial in patients with ischemic heart disease with heart failure. Emerging trends show their usefulness in patients with nonischemic heart failure. Statins exhibit pleiotropic effects in stabilizing the atherosclerotic plaques, improvement of endothelial function, inhibition of cell migration and proliferation, and reduction of inflammation and oxidative stress. They also improve autonomic function with an increased parasympathetic drive, downregulate the angiotensin II type I receptors, and induce angiogenesis.ConclusionThis article is a review on the current knowledge on statin use in heart failure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 12, Issue 6, August 2006, Pages 473–478
نویسندگان
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