In Vivo Effects of Myocardial Creatine Depletion on Left Ventricular Function Morphology and Lipid Metabolism: Study in a Mouse Model

Myocardial Cr depletion results in LV dysfunction, pathologic remodeling, and lipid accumulation. These alterations are completely reversible on normalization of Cr content. Cr metabolism may be an important target for pharmacologic intervention to increase myocardial efficiency and structural integrity of the failing heart.