کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2963421 1178558 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dysfunctional co-expression network analysis of familial hypercholesterolemia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Dysfunctional co-expression network analysis of familial hypercholesterolemia
چکیده انگلیسی

Familial hypercholesterolemia (FH) is an inherited disorder of blood lipid metabolism characterized by high serum low-density lipoprotein cholesterol levels and premature coronary artery disease. In this study, we used a system biology approach to identify co-expressed gene pairs that were potentially involved in the progression of FH and constructed a conserved co-expression network using these genes. A total of 4232 co-expressed relationships were identified and we verified the significance by random permutation. FH patients showed differences in lipoprotein and cholesterol metabolism in circulating monocytes and lymphocytes compared to healthy controls. We hope our study could aid in understanding of FH and could provide the basis for FH biomarker identification.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiology - Volume 62, Issue 1, July 2013, Pages 58–62
نویسندگان
, , , , , , , , , , ,